Publications

2008

Tissue-engineered endothelial and epithelial implants differentially and synergistically regulate airway repair
Brett G. Zani, Koji Kojim, Charles A. Vacanti, Elazer R. Edelman
Proc. Natl. Acad. Sci. USA, DOI: 10.1073/pnas.080246315. March 12, 2008           [ Abstract ] [ PDF ]

The effect of three-dimensional matrix-embedding of endothelial cells on the humoral and cellular immune response
Heiko Methe, Shmuel Hess, Elazer R. Edelman
Seminars in Immunology 20 (2008)117-122, DOI: 10.1016/j.smim.2007.12.005  [ PDF ]

2007

Adventitial endothelial implants reduce matrix metalloproteinase-2 expression and increase luminal diameter in porcine arteriovenous grafts
Helen M. Nugent, PhD, Robert Tjin Tham Sjin, PhD, Desmond White, BS, Luther G. Milton, LATG, Roberto J. Manson, MD, Jeffrey H. Lawson, MD, PhD, and Elazer R. Edelman, MD, PhD
Journal of Vascular Surgery Volume 46, Number 3, September 2007 [ PDF ]

Endothelial immunogenicity - A matter of matrix microarchitecture
Heiko Methe, Shmuel Hess, and Elazer R. Edelman
Vascular Biology - Concepts July 6, 2007
DOI: 10.1160/TH07-01-0043 [ PDF ]

Endothelial cell-matrix interactions determine maturation of dendritic cells
Heiko Methe, Shmuel Hess, and Elazer R. Edelman
European Journal of Immunology 2007. 37: 1773-1784
DOI: 10.1159/000067207 [ PDF ]

Matrix adherence of endothelial cells attenuates immune reactivity: induction of hyporesponsivenee in allo- and xenogeneic models
Heiko Methe, Adam Groothuis, Mohamed H. Sayegh, and Elazer R. Edelman
The FASEB Journal Express article fj.06-7051com. January 30, 2007
0892-6638/07/0021-0001 [ PDF ]

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2006

Cell-Matrix Contact Prevents Recognition and Damage of Endothelial Cells in States of Heightened Immunity
Heiko Methe, MD and Elazer R. Edelman, MD, PhD

Circulation July 4, 2006
DOI: 10.1002/eji.200636495 [ PDF ]

Tissue Engineering of Endothelial Cells and the Immune Response
H. Methe and E.R. Edelman

Elsevier Inc. Transplantation Proceedings, 38, 3293-3299 (2006)
DOI: 10.1016/j.transproceed.2006.10.052 [ PDF ]

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1999 - 2005

Matrix Embedding Alters the Immune Response Against Endothelial Cells In Vitro and In Vivo
Heiko Methe, MD; Helen M. Nugent, PhD; Adam Groothuis, MS; Philip Seifert, MS;
Mohamed H. Sayegh, MD; Elazer R. Edelman, MD, PhD
Circulation 2005
DOI: 10.1161/01.CIRCULATIONAHA.105.524991 [ PDF ]

Perivascular Endothelial Cell Tissue Engineering
Helen M. Nugent and Elazer R. Edelman
Handbook of Cardiovascular Cell Transplantation
2004; 26:347-367 [ PDF ]

Tissue Engineering Therapy for Cardiovascular Disease
Helen M. Nugent, Elazer R. Edelman
Circulation Research 2003;92:1068-1078 [ PDF ]

Perivascular Endothelial Implants Inhibit Intimal Hyperplasia in a Model of Arteriovenous Fistulae: A Safety and Efficacy Study in the Pig
Helen M. Nugent, Adam Groothuis, Philip Seifert, J. Luis Guerraro, Mark Nedelman, T. Mohanakumar, Elazer R. Edelman
Journal of Vascular Research 2002;39:524–533
DOI: 10.1159/000067207 [ PDF ]

Endothelial Implants Provide Long-Term Control of Vascular Repair in a Porcine Model of Arterial Injury
Helen M. Nugent, Ph.D. and Elazer R. Edelman, M.D., Ph.D.
Journal of Surgical Research 99, 228–234 (2001)
DOI:10.1006/jsre.2001.6198 [ PDF ]

Perlecan is required to inhibit thrombosis after deep vascular injury and contributes to endothelial cell-mediated inhibition of intimal hyperplasia
Matthew A. Nugent, Helen M. Nugent, Renato V. Iozzoi, Kristian Sanchack, and Elazer R. Edelman
PNAS
June 6, 2000, vol. 97, no. 12, 6727 [ PDF ]

Endothelial Implants Inhibit Intimal Hyperplasia After Porcine Angioplasty
Helen M. Nugent, Campbell Rogers, Elazer R. Edelman
Circulation Research 1999;84:384-391 [ PDF ]

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